Updated: September 26, 2014
Jaclyn Shepard
CBC Scholar: Class of 2010
Department of Chemical and Biological Engineering, NU; Advisor: Lonnie Shea
SHEA LAB WEBPAGE
Jaclyn successfully defended her thesis in March 2012. Her dissertation title was: "Engineering gene delivery from hydrogels for regenerative medicine applications". She is currently a Postdoctoral Associate at MIT, Dept. of Chemical Engineering, Lab of Paula Hammond.
PUBLICATIONS:
Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS. Matrix rigidity activates Wnt signaling through downregulation of Dickkopf-1. J Biol Chem. 2013 Jan 4;288(1):141-51. (PubMed)
Seidlits SK, Gower RM, Shepard JA, Shea LD. Hydrogels for lentiviral gene delivery. Expert Opin Drug Deliv. 2013 Apr;10(4):499-509. (PubMed)
Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS. Matrix rigidity activates Wnt signaling through downregulation of Dickkopf-1. J Biol Chem. 2013 Jan 4;288(1):141-51. (PubMed)
Shepard JA, Virani FR, Goodman AG, Gossett TD, Shin S, Shea LD. Hydrogel macroporosity and the prolongation of transgene expression and the enhancement of angiogenesis. Biomaterials. 2012 Oct;33(30):7412-21. (PubMed)
Shepard JA, Stevans AC, Holland S, Wang CE, Shikanov A, Shea LD. Hydrogel design for supporting neurite outgrowth and promoting gene delivery to maximize neurite extension. Biotechnol Bioeng. 2012 Mar;109(3):830-9. (PubMed)
Shepard JA, Wesson PJ, Wang CE, Stevans AC, Holland SJ, Shikanov A, Grzybowski BA, Shea LD. Gene therapy vectors with enhanced transfection based on hydrogels modified with affinity peptides. Biomaterials. 2011 Aug;32(22):5092-9. (PubMed)
Shepard JA, Huang A, Shikanov A, Shea LD. Balancing cell migration with matrix degradation enhances gene delivery to cells cultured three-dimensionally within hydrogels.J Control Release. 2010 Aug 17;146(1):128-35. (PubMed)
Barbolina MV, Kim M, Liu Y, Shepard J, Belmadani A, Miller RJ, Shea LD, Stack MS. Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma. Mol Cancer Res. 2010 May;8(5):653-64. (PubMed)
AWARDS AND HONORS:
CBC Scholar 2010-2011
Northwestern University Department of Chemical and Biological Engineering Terminal Year Fellowship 2010-2011
Acceptance into Kellogg’s Management for Scientists and Engineers Program